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Gut bacteria mostly compete—but cooperation finds a way
edited by Sadie Harley , reviewed by Robert Egan
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Add as preferred source Understanding how bacteria influence one another is essential for understanding how microbial communities are formed and maintained. Researchers at Umeå University have now systematically mapped interactions between common gut bacteria, creating one of the most comprehensive datasets of its kind.
The human gut contains hundreds of microbial species that form complex communities linked to digestion, immune function and resistance to infection. Despite their importance, interactions among many microbial species remain poorly understood.
The results showed that most interactions were negative, meaning one species limited the growth of another. A major reason was that bacteria altered their environment, particularly by changing its pH and making it more acidic.
"Our results show that competition is a dominant feature of the gut microbiome. At the same time, we found specific examples of cooperation and identified the molecular mechanisms behind them," says Bolor Buyanbadrakh, a postdoctoral fellow at the Department of Chemistry at Umeå University and first author of the study.
One finding was that Clostridium perfringens promotes the growth of Mediterraneibacter gnavus through the release of extracellular vesicles , tiny particles released by bacteria that can carry molecules between cells. The study provides evidence that such vesicles can directly influence the growth of another bacterial species.
The researchers also discovered that Veillonella parvula can increase the pH of its surroundings, counteracting acidification caused by other bacteria. This change allowed acid-sensitive species, such as Parabacteroides merdae, to grow more effectively, even in more complex microbial communities.
"Understanding how bacteria influence each other is essential if we want to predict or eventually manipulate microbiome composition in a rational way. Our work provides both a large interaction data set and mechanistic insights that move the field in that direction," says André Mateus, an assistant professor at the Department of Chemistry, team leader at The Laboratory for Molecular Infection Medicine Sweden (MIMS) and senior author of the study.
Bolor Buyanbadrakh et al, Systematic profiling of growth interactions in human gut microbiome species, Nature Communications (2026). DOI: 10.1038/s41467-026-76526-z
Journal information: Nature Communications
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