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The 39-year-old Argentina forward is signed with Inter Miami until 2028.
But, in an emotional tribute to his dad, he hinted at retirement as he said: "I don't know how to carry on. I used to just play football, and now I'm really not sure if I'll carry on doing it for much longer."
He has scored a combined 921 goals for Barcelona, Paris St-Germain, Inter Miami and Argentina.
BBC Sport looks at some of the most iconic moments of his remarkable career.
Messi unsure he will play 'much longer' after father's death
At the age of 19, he scored all of Barcelona's goals in a 3-3 draw against rivals Real Madrid on 10 March 2007 - his first at the Camp Nou - including a brilliant last-minute finish after beating a couple of defenders.
This was arguably the moment he became a household name.
Just over a month after that hat-trick, Messi scored a goal he has probably never surpassed in the rest of his glorious career.
It came in a 5-2 win over Getafe in the Copa del Rey semi-final first leg on 18 April 2007.
In a strike with remarkable similarities to compatriot Diego Maradona's (non-handball) effort against England in the 1986 World Cup, Messi picked the ball up in his own half, beat about five defenders, went around the goalkeeper and slotted home.
Ridiculous as it sounds now, back in 2009 some English football fans and journalists questioned whether Messi could do it against English opponents in Europe - having failed to net in 10 Champions League appearances against Premier League sides.
But there were no more doubts when Messi rose highest in the box to head home Xavi's cross in his first Champions League final against Manchester United - and the first game billed as Messi v Cristiano Ronaldo.
Two years later he would score in another final win over Sir Alex Ferguson's men to claim the third of his four Champions League winners' medals.
Messi scored four goals for the first time in his career as he took Arsenal to the cleaners in the 2010 Champions League quarter-final for a 4-1 home-leg win.
The pick of the bunch was his chip over keeper Manuel Almunia to complete his hat-trick.
An honourable mention goes to his five-goal haul two years later against Bayer Leverkusen in a 7-1 last-16 success.
He is the second top scorer in Champions League history with 129, behind Ronaldo.
Messi broke Barcelona's goalscoring record - aged just 24 - in some style with a hat-trick in a 5-3 victory over Granada on 20 March 2012.
He equalled Cesar Rodriguez's 60-year-old record of 232 goals with his first, broke it with his second and extended the record with a third.
A stat so amazing you have to go back to double check to make sure it really happened.
In 2012 Messi hit his 91st goal of the year in Barcelona's 3-1 win at Real Valladolid on 22 December.
It earned him a place in the Guinness Book of Records. , external
He netted 79 goals for Barcelona and 12 for Argentina - in a total of 69 games for club and country.
It was enough to earn Messi a then-unprecedented fourth consecutive Ballon d'Or - even though he only won the Copa del Rey in 2012 for all those goals.
This was the second major record Messi broke with a hat-trick.
He hit three in a 5-1 win over Sevilla on 22 November 2014 to become the top scorer in La Liga's history.
Messi equalled Telmo Zarra's 251-goal mark - set in 1955 by the Athletic Club forward - with a free-kick, before breaking it and stretching it with a third.
He ended up on 474 goals, far clear of Ronaldo's 311 for Real Madrid.
All the narratives seemed to come together in Barcelona's 3-2 win at Real Madrid on 23 April 2017.
Messi popped up with an injury-time goal, sweeping home a first-time shot from the edge of the area. It was an El Clasico winner, his 500th Barcelona goal and it sent his side top of the table - although Real would go on to win the league at the end of that season.
For good measure, he pulled out an iconic celebration when he took off his shirt and held it out so the Bernabeu faithful could see his name.
The almost unthinkable happened in August 2021 as Messi left Barcelona on a free transfer.
After 21 years, 672 goals and 35 trophies, he had to leave because the club could not afford to honour the new contract they agreed because of La Liga's salary limit.
In an emotional news conference, a tearful Messi said: "My family and I were convinced we were going to stay here, at home.
"I don't want to leave this club - it's a club I love and this is a moment I didn't expect."
Despite being linked with Manchester City, he joined Paris St-Germain.
On 11 July, 2021, Messi - at the age of 34 - won his first senior international trophy as Argentina beat Brazil 1-0 in the Copa America final at the Maracana.
He was named player of the tournament after scoring four goals.
An emotional Messi fell to the ground as the full-time whistle blew and was thrown in the air by his team-mates as they celebrated.
He won his second Copa America three years later.
It was a triumph and moment that looked like it would never happen, with Messi having previously retired from international football before coming back.
It was always the thing held against him in debates about whether he was the greatest footballer of all time.
Messi scored two goals, and his effort in the 2022 shootout, as Argentina beat France on penalties after a 3-3 draw in the best World Cup final ever.
He was named player of the tournament, having netted seven times - including efforts in each knockout round.
Messi won another two Ballons d'Or after leaving Barcelona - one at Paris St-Germain and one at Inter Miami - to extend his record haul to eight.
His last one came in October 2023 after he won the World Cup and helped his Major League Soccer side lift the Leagues Cup for their first trophy.
"I couldn't imagine having the career I've had and everything I've achieved, the fortune I've had...
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