Novak Djokovic suffered defeat and struggled physically in his first match since Wimbledon as he was upset by Thiago Agustin Tirante in a sapping three-set contest at the Cincinnati Open. <p>Djokovic, inactive on the ATP Tour since losing to Jannik Sinner at the grass-court Grand Slam on July 10, won the first set 6-2 but then lost the next two 6-4 as he battled the heat and humidity in Ohio, even appearing to vomit at one stage.</p><p>The 24-time major champion won an 18-minute third game of the second set, fending off four break points over nine deuces, before taking a medical timeout, while he dropped to his hands and knees at certain points in a match that lasted two hours and 45 minutes.</p><ul><li><a href="https://www.skysports.com/tennis/scores-schedule"><strong>Latest scores and results from tennis' Cincinnati Open</strong></a></li><li><strong><a href="https://www.sky.com/tv/sports?dcmp=Ilc_skysports_nc_articlelink" target="_blank">Latest Sky Sports deals </a>or <a href="https://www.nowtv.com/watch-sky-sports-online?DCMP=ilc_skysports_nc_articlelink" target="_blank">stream tennis with no contract</a></strong></li><li><a href="https://qrcode.skysports.com/skysports/ContentPromo" target="_blank"><strong>Download Sky Sports app for analysis, news and video</strong></a></li></ul><h3>Tirante revels in 'best win of career'</h3><p>Tirante, who can look forward to a third-round meeting with Spain's Martin Landaluce, made the decisive break at 4-4 in the decider after converting his fourth break point of the game and then closed out the win on serve.</p><widget id="1"></widget><p>He said afterwards: "This is the best win of my career. I really did a good job inside the court. I managed very well the nerves of playing against a legend like Novak. Now I feel relieved.</p><p>"It is all so much pressure when you cannot break [serve]. I had so many points to break and I couldn't, so that was the key. Keep believing in myself with my team and think about it after the match."</p><p>Djokovic was the third seed in Cincinnati despite sitting fifth in the world rankings, with world No 1 Sinner withdrawing due to a knee injury and world No 3 Carlos Alcaraz also absent as he continues to deal with a lingering wrist issue.</p><p>Top seed Alexander Zverev plays Britain's Cameron Norrie in the second round overnight.</p><h3>Britain's Boulter out of women's tournament</h3> <widget id="2"></widget><p>British women's No 2 <strong>Katie Boulter</strong> saw her campaign end in the second round with a 6-3 6-3 defeat to Wimbledon champion Linda Noskova.</p><p>Noskova, who served 10 aces compared to Boulter's none, converted four of the nine break points she fashioned and was only broken once in return.</p><p>Boulter had snapped a five-match losing streak on the WTA Tour by beating America's Katie Volynets in three sets in the first round, winning the decider after losing the second set 6-0.</p><p><strong>Watch the ATP and WTA Tours live on Sky Sports. The US Open is also live on Sky Sports from August 30. </strong><strong><a href="https://www.nowtv.com/watch-sky-sports-online?DCMP=ilc_skysports_nc_articlelink">Stream tennis with NOW</a>.</strong></p>