Former NFL QB Matt Hasselbeck part of latest CTE frontier

Matt Hasselbeck took some nasty hits to the head during his 17-year NFL career, four years at Boston College and a childhood full of sports, but the quarterback seems to have emerged from more than two decades of collisions relatively unscathed, enjoying middle adulthood with his wife and three children.

The 50-year-old knows that some of his friends and former teammates haven’t been as lucky.

That’s why the three-time Pro Bowl selection recently spent two days at Boston University, going through a battery of scans and tests to determine how much all those collisions affected his brain. The hope is that it will be a small step toward a goal that has eluded doctors — diagnosing chronic traumatic encephalopathy in the living.

“They need guys like me — they need people who are feeling good to step up to the plate and volunteer,” Hasselbeck said. “I played quarterback, so I didn’t take some of the hits that a lot of my teammates took.

“But the guys who were blocking for me, or playing special teams, or trying to get the ball back for me on defense, I wanted to do something. They had my back, so in a way I’d like to have their back.”

CTE puts harsh spotlight on NFL, college football

A degenerative brain disease that has been linked to concussions and other head trauma common in military combat and contact sports, CTE has been diagnosed in more than 100 former NFL players, casting a pall over the United States’ most popular sports league. Some high-profile football players diagnosed with CTE after their deaths include Hall of Famers like linebacker Junior Seau and quarterback Ken Stabler , along with former Patriots tight end Aaron Hernandez .

Right now, CTE can only be diagnosed after death.

CTE can affect regions of the brain involved with regulating behavior and emotions . This can lead to memory loss, depression, violent mood swings and other cognitive and behavioral issues, though researchers note these symptoms can also be linked to other illnesses.

Hasselbeck’s participation is just a small part of a study that Michael Alosco, co-director of clinical research at the Boston University CTE Center, hopes will expand to hundreds of participants in multiple locations. Alosco is the principal investigator in Boston and there are also sites in California, Arizona, Texas and Florida with potentially more to come.

The study seeks two types of people : Those who played professional or college football and those who have been diagnosed with Alzheimer’s disease and never played contact or collision sports and have no history of repetitive head impacts.

Alosco said there are many similarities between Alzheimer’s and CTE because both are degenerative brain diseases, but there are also some key differences, and mapping out those discrepancies is key to figuring out a way to diagnose CTE properly.

“We’ve applied what we’ve known worked for Alzheimer’s disease, but we’ve learned it does not work for CTE,” Alosco said. “We’ve really got to push discovery efforts and find the marker that’s specific to the protein of CTE versus Alzheimer’s because they’re different.

“How we’re going to get there is through the research we’re doing right now.”

Nicholas Ashton, the principal investigator in Phoenix, said roughly 10 patients have participated at the Arizona site. He said that currently, diagnosing CTE in the living is mostly guesswork because so many of the symptoms mimic Alzheimer’s.

“The more people involved, the more information we get and the closer we get to an answer,” Ashton said. “Treatments exploded with Alzheimer’s once we were able to accurately diagnose. We’re trying to get to the same spot with CTE.”

NFL QB says tests are eye-opening

Hasselbeck said he went through a variety of mental tests — like counting backward from 100 by sevens and reciting the alphabet backward. He also had a blood sample taken, an MRI on his brain and a PET (positron emission tomography) scan that injects a small amount of safe radioactive tracer that maps out the brain’s function.

The former quarterback said the procedures were eye-opening and humbling.

“I’ve got a healthy respect for people who are dealing with serious brain trauma, whether it’s tumors or cancer,” Hasselbeck said. “I walked in there feeling completely healthy and you still get a little anxious when you’re doing a brain scan, an MRI. You come out and you’re looking at your brain.”

Hasselbeck is also donating his brain for research after he dies.

Not everyone in the study is a famous former NFL player.

Bryan Savage, a 56-year-old who lives in Maryland, is a former linebacker at Union College in Schenectady, New York — an NCAA Division III school. He traveled to Boston for the study and also has committed to donating his brain.

Savage said he’s lucky to be relatively healthy but that he’s been diagnosed with depression and ADHD over the past few years.

“I was interested because of some of the things that I’ve gone through physically and mentally,” Savage said. “You wonder if it’s just getting older, a midlife crisis or if it’s related to any brain trauma I might have had playing football.”

Savage praised the researchers who were with him during the study and said he was relieved to find out his brain scans look normal for a man in his mid-50s. He’s reached out to some of his former teammates, encouraging them to get involved in the study.

“I’ll talk to some of my former friends and they’re going through a lot of the same things,” Savage said. “They’ll say — ‘Why do I feel like this? I’ve never been depressed. Things that I used to be passionate about I don’t care about anymore.’”

Alosco said the main reason Alzheimer’s research is much more advanced than CTE research is sheer numbers: Alzheimer’s research dates back decades and there have been countless people who have been studied.

By comparison, CTE research is relatively new. Volunteers like Hasselbeck and Savage are crucial to bridge the gap. The National Institutes of He...

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